In 1995, Ultram gained Food and Drug Administration (FDA) approval. Prescribed to manage moderate to moderately severe pain, Ultram is an analgesic. Working directly with the brain and spinal cord, Ultram minimizes pain signals passed from one nerve to another. Ultram should only be used as long as prescribed by a doctor. Usually, it is taken every 4 to 6 hours as needed; however, the dose should never be increased more frequently than prescribed. Ultram can be habit-forming. Potentially, Ultram might cause dizziness, weakness, incoordination, nausea or vomiting, stomach upset, constipation, headache, drowsiness, anxiety, irritability or dry mouth. Reporting a complete medical history to a medical provider is required before using Ultram.